Cooper C M, Gordon D L, Reid C, Philpot C R
Department of Microbiology and Infectious Diseases, Flinders Medical Centre, Bedford Park, South Australia.
Australas J Dermatol. 1992;33(2):93-6. doi: 10.1111/j.1440-0960.1992.tb00088.x.
A case of recurrent cutaneous cryptococcosis in an immunocompromised patient is described. The patient presented with a non-healing cutaneous ulcer due to infection with Cryptococcus neoformans. Extensive investigation failed to reveal any evidence of associated systemic cryptococcosis. Treatment with oral fluconazole resulted in complete resolution of the ulcer but after several months a second cutaneous cryptococcal lesion appeared, strongly suggesting dissemination from an underlying systemic focus. This case illustrates the hazards associated with making a diagnosis of isolated cutaneous cryptococcosis and the necessity for prolonged follow-up of patients who present in this way.
本文描述了一例免疫功能低下患者复发性皮肤隐球菌病的病例。该患者因新型隐球菌感染出现了一个不愈合的皮肤溃疡。广泛检查未发现任何相关系统性隐球菌病的证据。口服氟康唑治疗使溃疡完全愈合，但数月后出现了第二个皮肤隐球菌病灶，强烈提示来自潜在系统性病灶的播散。该病例说明了诊断孤立性皮肤隐球菌病的风险以及对以这种方式就诊的患者进行长期随访的必要性。
