Cooper D M, Mons N, Karpen J W
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA.
Nature. 1995 Mar 30;374(6521):421-4. doi: 10.1038/374421a0.
Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry into the cell. Oscillations in cellular cyclic AMP levels are predicted to arise because of feedback inhibition of adenylyl cyclase by Ca2+. Such findings inextricably intertwine cellular signalling by cAMP and internal Ca2+ and extend the known regulatory modes available to cAMP.
腺苷酸环化酶是典型的第二信使生成器。几乎所有八个克隆的腺苷酸环化酶都受磷脂酶C途径的一个或另一个分支调节。功能和超微结构研究表明，腺苷酸环化酶与钙离子进入细胞的位点密切相关。由于Ca2+对腺苷酸环化酶的反馈抑制作用，预计细胞内环状AMP水平会出现振荡。这些发现将cAMP和细胞内Ca2+的细胞信号传导紧密地交织在一起，并扩展了cAMP已知的调节模式。
