Metz C N
North Shore-LIJ Research Institute, 350 Community Drive, Manhasset, New York 11030, USA.
Cell Mol Life Sci. 2003 Jul;60(7):1342-50. doi: 10.1007/s00018-003-2328-0.
Following tissue damage, host wound healing ensues. This process requires an elaborate interplay between numerous cell types which orchestrate a series of regulated and overlapping events. These events include the initiation of an antigen-specific host immune response, blood vessel formation, as well as the production of critical extracellular matrix molecules, cytokines and growth factors which mediate tissue repair and wound closure. Connective tissue fibroblasts are considered essential for successful wound healing; however, their origin remains a mystery. A unique cell population, known as fibrocytes, has been identified and characterized. One of the unique features of these blood-borne cells is their ability to home to sites of tissue damage. This article reviews the identification and characterization of fibrocytes, summarizes the potential role of fibrocytes in the numerous steps of the wound-healing process and highlights the potential role of fibrocytes in fibrotic disease pathogenesis.
组织损伤后，机体开始伤口愈合。这个过程需要多种细胞类型之间精心的相互作用，这些细胞协调一系列有调控且相互重叠的事件。这些事件包括启动抗原特异性的机体免疫反应、血管形成，以及产生关键的细胞外基质分子、细胞因子和生长因子，它们介导组织修复和伤口闭合。结缔组织成纤维细胞被认为是伤口成功愈合所必需的；然而，它们的来源仍是个谜。一种独特的细胞群体，即纤维细胞，已被识别和表征。这些血源性细胞的一个独特特征是它们能够归巢到组织损伤部位。本文综述了纤维细胞的识别和表征，总结了纤维细胞在伤口愈合过程众多步骤中的潜在作用，并强调了纤维细胞在纤维化疾病发病机制中的潜在作用。
