来自全缘麻风树的二萜类化合物、倍半萜类化合物和一种倍半萜-香豆素共轭物。

Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima.

作者信息

Sutthivaiyakit Somyote, Mongkolvisut Wantana, Prabpai Samran, Kongsaeree Palangpon

机构信息

Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.

出版信息

J Nat Prod. 2009 Nov;72(11):2024-7. doi: 10.1021/np900342b.

DOI:10.1021/np900342b

PMID:19943622

Abstract

Five new compounds, 2alpha-hydroxyjatropholone (1), 2beta-hydroxyjatropholone (2), 1,5-dioxo-2,3-dihydroxyrhamnofola-4(10),6,11(18),15-tetraene (3), 2-keto-5-hydroxyguai-3,11-diene (4), and a sesquiterpene-coumarin conjugate, jatrophadioxan (5), and nine known compounds have been isolated from the roots of Jatropha integerrima. The structures were established from spectroscopic data, and the relative configuration of 1 was confirmed by X-ray crystallography. Six diterpenes were evaluated for their antiplasmodial, antituberculosis, and cytotoxic activities.

摘要

从全缘麻风树的根中分离出了5种新化合物，即2α-羟基麻风树醇酮（1）、2β-羟基麻风树醇酮（2）、1,5-二氧代-2,3-二羟基鼠李诺醇-4(10),6,11(18),15-四烯（3）、2-酮基-5-羟基愈创木-3,11-二烯（4）以及一种倍半萜-香豆素共轭物麻风树二氧杂环烷（5），还有9种已知化合物。通过光谱数据确定了其结构，并通过X射线晶体学证实了1的相对构型。对6种二萜类化合物进行了抗疟、抗结核和细胞毒性活性评估。