Vujaskovic Z, Rosen E L, Blackwell K L, Jones E L, Brizel D M, Prosnitz L R, Samulski T V, Dewhirst M W
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Int J Hyperthermia. 2003 Sep-Oct;19(5):498-506. doi: 10.1080/0265673031000121517.
The objective of this study was to determine whether neoadjuvant chemotherapy in combination with hyperthermia (HT) would improve oxygenation in locally advanced breast tumours. The study describes a new optimized ultrasound guided technique of pO2 measurement using Eppendorf polarographic oxygen probes in 18 stage IIB-III breast cancer patients. Prior to treatment, tumour hypoxia (median pO2<10 mmHg) was present in 11/18 patients (average median pO2=3.2 mmHg). Seven patients had well oxygenated tumours (median pO2 of 48.3 mmHg). Eight patients with hypoxic tumours prior to treatment had a significant improvement (p=0.0008) in tumour pO2 after treatment (pO2 increased to 19.2 mmHg). In three patients, tumours remained hypoxic (average median pO2=4.5 mmHg). The advantages of the ultrasound guided pO2 probe are in the accuracy of the Eppendorf electrode placement in tumour tissue, the ability to monitor electrode movement through the tumour tissue during the measurement and the ability to avoid electrode placement near or in large blood vessels by using colour Doppler imaging. The results of this preliminary study suggest that the combination of neoadjuvant chemotherapy and hyperthermia improves oxygenation in locally advanced breast tumours that are initially hypoxic.
本研究的目的是确定新辅助化疗联合热疗（HT）是否会改善局部晚期乳腺肿瘤的氧合情况。该研究描述了一种新的优化超声引导技术，用于在18例IIB - III期乳腺癌患者中使用Eppendorf极谱氧探头测量pO2。治疗前，11/18例患者存在肿瘤缺氧（中位pO2<10 mmHg）（平均中位pO2 = 3.2 mmHg）。7例患者的肿瘤氧合良好（中位pO2为48.3 mmHg）。8例治疗前肿瘤缺氧的患者治疗后肿瘤pO2有显著改善（p = 0.0008）（pO2升至19.2 mmHg）。3例患者的肿瘤仍处于缺氧状态（平均中位pO2 = 4.5 mmHg）。超声引导下pO2探头的优点在于Eppendorf电极在肿瘤组织中放置的准确性、测量过程中监测电极在肿瘤组织中移动的能力以及通过彩色多普勒成像避免电极放置在大血管附近或内部的能力。这项初步研究的结果表明，新辅助化疗和热疗的联合应用可改善最初缺氧的局部晚期乳腺肿瘤的氧合情况。
