Lampe J B, Gossrau G, Herting B, Kempe A, Sommer U, Füssel M, Weber M, Koch R, Reichmann H
Department of Neurology, University of Technology, Dresden, Germany.
Eur Neurol. 2003;50(2):64-8. doi: 10.1159/000072500.
Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Several antigens have been associated with IPD using serological methods. We systematically analysed HLA class I and II alleles in 45 German Caucasian IPD patients using sequence-specific oligonucleotides and sequence-specific primer technology. Applying Bonferroni adjusted p values, we demonstrate a statistically significant increase of the DQB1*06 allele (p = 0.002) in IPD which may indicate an association between IPD and the immune system. Alternatively, HLA alleles might be in linkage disequilibrium with genes located next to the HLA locus.
