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Chemoenzymatic syntheses of (-)-1-deoxymannojirimycin (DMJ) and its naturally occurring 6-O-alpha-L-rhamnopyranosyl glycoside.

作者信息

Banwell Martin G, Ma Xinghua, Asano Naoki, Ikeda Kyoko, Lambert John N

机构信息

Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.

出版信息

Org Biomol Chem. 2003 Jun 21;1(12):2035-7. doi: 10.1039/b304063a.

DOI:10.1039/b304063a
PMID:12945891
Abstract

The naturally occurring sugar mimetic alkaloids 1-deoxymannojirimycin (DMJ, 1) and 6-O-alpha-L-rhamnopyranosyl-DMJ (2) have each been prepared in a completely stereoselective manner from the cis-1,2-dihydrocatechol 3, itself obtained in enantiomerically pure form by microbial oxidation of chlorobenzene.

摘要

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