Fujii Naotaka, Graybiel Ann M
Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25-618, Cambridge, MA 02139, USA.
Science. 2003 Aug 29;301(5637):1246-9. doi: 10.1126/science.1086872.
Complex biological systems such as human language and the genetic code are characterized by explicit markers at the beginning and end of functional sequences. We report here that macaque prefrontal cortical neurons exhibit phasic peaks of spike activity that occur at the beginning and endpoint of sequential oculomotor saccade performance and have the properties of dynamic start- and end-state encoders accompanying responses to sequential actions. Sequence bounding may thus reflect a general mechanism for encoding biological information.
诸如人类语言和遗传密码这样的复杂生物系统，其特征在于功能序列的开头和结尾有明确的标记。我们在此报告，猕猴前额叶皮层神经元表现出峰电位活动的相位峰值，这些峰值出现在顺序性眼球运动扫视行为的开头和终点，并且具有伴随对顺序动作反应的动态起始和结束状态编码器的特性。因此，序列边界可能反映了一种编码生物信息的通用机制。
