Jakes R W, Day N E, Khaw K-T, Luben R, Oakes S, Welch A, Bingham S, Wareham N J
Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Cambridge, UK.
Eur J Clin Nutr. 2003 Sep;57(9):1089-96. doi: 10.1038/sj.ejcn.1601648.
This study describes the associations between sedentary behaviour (television viewing) and participation in vigorous recreational activity with obesity and with biomarkers of cardiovascular disease (CVD) risk profile.
Cross-sectional analysis of the EPIC-Norfolk cohort study.
The study is a population-based study of participants living in Norfolk, UK.
A total of 15 515 men and women aged between 45 and 74 y, recruited through General Practice lists, who completed the detailed physical activity questionnaire.
Following exclusion of those with self-reported myocardial infarction, stroke and diabetes, 14 189 participants remained for the analysis. Self-reported television viewing was positively and participation in vigorous activity negatively associated with markers of obesity, blood pressure and plasma lipids. In multiple regression analysis, adjusting for age, alcohol, smoking, treatment for hypertension, vigorous and total physical activity, these associations remained significant. For women who participated in more than 1 h/week of vigorous activity and who watched fewer than 2 h of television each day, the adjusted mean body mass index was 1.92 kg/m(2) less than for women who reported participating in no vigorous activity and who watched more than 4 h of television each day (P<0.001). The equivalent figure for men was 1.44 kg/m(2) (P<0.001). In a similar analysis, with blood pressure as the outcome, mean diastolic blood pressure difference between the extreme groups of vigorous activity and television viewing was 3.6 mmHg in men (P<0.001) and 2.7 mmHg (P=0.001) in women.
These data suggest that time spent participating in vigorous recreational physical activity and television viewing, an indicator of a sedentary lifestyle, are associated with obesity and markers of CVD disease risk independent of total reported physical activity. Whether these observations represent the true underlying aetiological relations or are a manifestation of the different precision with which the subdimensions of activity are measured remains uncertain.
本研究描述久坐行为（看电视）以及参与剧烈休闲活动与肥胖和心血管疾病（CVD）风险特征生物标志物之间的关联。
对欧洲癌症与营养前瞻性调查（EPIC）-诺福克队列研究进行横断面分析。
该研究是以英国诺福克郡居民为基础的人群研究。
通过全科医生名单招募了15515名年龄在45至74岁之间的男性和女性，他们完成了详细的体力活动问卷。
排除那些自我报告有心肌梗死、中风和糖尿病的人后，剩余14189名参与者进行分析。自我报告的看电视时间与肥胖、血压和血脂指标呈正相关，而参与剧烈活动与之呈负相关。在多元回归分析中，调整年龄、饮酒、吸烟、高血压治疗、剧烈和总体力活动后，这些关联仍然显著。对于每周参与超过1小时剧烈活动且每天看电视少于2小时的女性，调整后的平均体重指数比那些报告不参与剧烈活动且每天看电视超过4小时的女性低1.92kg/m²（P<0.001）。男性的相应差值为1.44kg/m²（P<0.001）。在一项以血压为结果的类似分析中，剧烈活动和看电视极端组之间的男性平均舒张压差异为3.6mmHg（P<0.001），女性为2.7mmHg（P=0.001）。
这些数据表明，参与剧烈休闲体育活动的时间以及久坐生活方式的一个指标——看电视时间，与肥胖和CVD疾病风险标志物相关，且独立于报告的总体力活动。这些观察结果是代表真正的潜在病因关系，还是活动子维度测量精度不同的一种表现，仍不确定。
