肥胖与心血管疾病和 2 型糖尿病的危险因素：在 1958 年英国队列研究中探究中年时期体力活动和久坐行为的作用。

Obesity and risk factors for cardiovascular disease and type 2 diabetes: investigating the role of physical activity and sedentary behaviour in mid-life in the 1958 British cohort.

机构信息

Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

出版信息

Atherosclerosis. 2014 Apr;233(2):363-369. doi: 10.1016/j.atherosclerosis.2014.01.032. Epub 2014 Jan 27.

DOI:10.1016/j.atherosclerosis.2014.01.032

PMID:24530764

Abstract

OBJECTIVE

A key public health priority is to minimise obesity-related health consequences. We aim to establish whether physical activity (PA) or less sedentary behaviour ameliorate associations of obesity with biomarkers for cardiovascular disease (CVD) and type 2 diabetes.

METHODS

Data on obesity (33 y), PA (42 y), TV-viewing and health biomarkers (45 y) are from the 1958 British birth cohort (N=9377).

RESULTS

Obesity was associated with an adverse biomarker profile for CVD and type 2 diabetes. For PA, men active≥1/week had 1.09% (0.28, 1.90) lower diastolic blood pressure (DBP) than less active men; triglycerides were 2.08% (0.52, 3.64) lower per unit higher PA (on 4-point scale). TV-viewing was independently associated with several biomarkers, e.g. per unit higher TV-viewing (on 4-point scale) DBP was raised by 0.50% (0.09, 0.90) and triglycerides by 3.61% (1.58, 5.64). For both TV-viewing and PA, associations with HbA1c were greatest for the obese (pinteraction≤0.04): compared to a reference value of 5.20 HbA1c% in non-obese men viewing 0-1 h/day, HbA1c% differed little for those viewing>3 h/day; among obese men HbA1c% was 5.36 (5.22, 5.51) and 5.65 (5.53, 5.76), for 0-1 and >3 h/day respectively. For PA in non-obese men, the reduction associated with activity≥1/week was negligible compared to a reference value of 5.20 HbA1c% for those less active; but there was a reduction among obese men, HbA1c% was 5.50 (5.40, 5.59) vs 5.66 (5.55, 5.77) respectively.

CONCLUSION

Reduced TV-viewing and prevention of infrequent activity have greatest beneficial associations for glucose metabolism among the obese, with benefits for other biomarkers across obese and non-obese groups.

摘要

目的

减少肥胖相关的健康后果是当前公共卫生的一个重点。本研究旨在评估体力活动或减少久坐行为是否可以改善肥胖与心血管疾病（CVD）和 2 型糖尿病生物标志物之间的关联。

方法

1958 年英国出生队列（N=9377）的数据包括肥胖（33 岁）、体力活动（42 岁）、看电视时间和健康生物标志物（45 岁）。

结果

肥胖与 CVD 和 2 型糖尿病的生物标志物谱不良有关。对于男性体力活动者，每周活动≥1 次的人群其舒张压（DBP）比不活跃的男性低 1.09%（0.28，1.90）；体力活动每增加 1 单位（4 分制），甘油三酯降低 2.08%（0.52，3.64）。看电视时间与多种生物标志物独立相关，例如，看电视时间每增加 1 单位（4 分制），DBP 升高 0.50%（0.09，0.90），甘油三酯升高 3.61%（1.58，5.64）。对于 TV 观看时间和体力活动，与 HbA1c 的关联在肥胖人群中最大（p 交互作用≤0.04）：与非肥胖男性中参考值 5.20%的 HbA1c 相比，每天观看 0-1 小时的人群 HbA1c 值差异不大；而每天观看>3 小时的肥胖男性的 HbA1c 值分别为 5.36（5.22，5.51）和 5.65（5.53，5.76）。对于非肥胖男性，与每周活动≥1 次相关的 HbA1c 降低与参考值 5.20%相比可忽略不计；但在肥胖男性中，HbA1c 值降低，分别为 5.50（5.40，5.59）和 5.66（5.55，5.77）。