Gu Sai, Tang Chengwei, Liu Chunlun
Department of Gastroenterology, First Hospital, Chongqing Medical University, Chongqing 400016, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Apr;34(2):325-6.
To investigate the relationship of the symptoms of duodenogastric reflux (DGR) with the quantity of intragastric bilirubin.
An apparatus (Bilitec 2000) was used for the monitoring of 24-hour intragastric bile in 18 menopause patients with functional dyspepsia (MPFD) accompanied with the symptoms, such as heartburn, epigastric pain, nausea and vomiting.
In most of the time, the symptoms of DGR appeared when intragastric bilirubin could be detected by Bilitec 2000. Furthermore, the severity of symptoms showed good correlation with the amount of bile refluxed into stomach.
It may be not necessary to monitor 24-hour intragastric bilirubin by using Bilitec 2000 for only diagnosis of DGR. To obtain objective evidences for DGR, the monitoring duration may be decided on the basis of obvious symptoms. This modification would be helpful to enhancing the compliance of patients in clinical trial.
探讨十二指肠胃反流（DGR）症状与胃内胆红素量的关系。
采用一种仪器（Bilitec 2000）对18例伴有烧心、上腹痛、恶心和呕吐等症状的绝经后功能性消化不良患者（MPFD）进行24小时胃内胆汁监测。
大多数时间，当Bilitec 2000能检测到胃内胆红素时，DGR症状出现。此外，症状的严重程度与反流至胃内的胆汁量呈良好相关性。
仅为诊断DGR，可能无需使用Bilitec 2000监测24小时胃内胆红素。为获得DGR的客观证据，监测时长可根据明显症状来确定。这种调整将有助于提高患者在临床试验中的依从性。
