Schoenbaum Geoffrey, Setlow Barry, Saddoris Michael P, Gallagher Michela
Department of Psychology, Johns Hopkins University, 25 Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA.
Neuron. 2003 Aug 28;39(5):855-67. doi: 10.1016/s0896-6273(03)00474-4.
Certain goal-directed behaviors depend critically upon interactions between orbitofrontal cortex (OFC) and basolateral amygdala (ABL). Here we describe direct neurophysiological evidence of this cooperative function. We recorded from OFC in intact and ABL-lesioned rats learning odor discrimination problems. As rats learned these problems, we found that lesioned rats exhibited marked changes in the information represented in OFC during odor cue sampling. Lesioned rats had fewer cue-selective neurons in OFC after learning; the cue-selective population in lesioned rats did not include neurons that were also responsive in anticipation of the predicted outcome; and the cue-activated representations that remained in lesioned rats were less associative and more often bound to cue identity. The results provide a neural substrate for representing acquired value and features of the predicted outcome during cue sampling, disruption of which could account for deficits in goal-directed behavior after damage to this system.
某些目标导向行为严重依赖于眶额皮质（OFC）和基底外侧杏仁核（ABL）之间的相互作用。在此，我们描述了这种协同功能的直接神经生理学证据。我们在完整大鼠和ABL损伤大鼠学习气味辨别问题时记录了OFC的活动。当大鼠学习这些问题时，我们发现损伤大鼠在气味线索采样期间OFC所代表的信息出现了显著变化。学习后，损伤大鼠的OFC中线索选择性神经元较少；损伤大鼠中的线索选择性群体不包括在预期预测结果时也有反应的神经元；并且损伤大鼠中剩余的线索激活表征关联性较低，且更常与线索特征相关联。这些结果为在线索采样期间表征习得价值和预测结果的特征提供了神经基础，该系统受损后这种表征的破坏可能导致目标导向行为的缺陷。
