Saddoris Michael P, Gallagher Michela, Schoenbaum Geoffrey
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, 25 Ames Hall, Baltimore, Maryland 21218, USA.
Neuron. 2005 Apr 21;46(2):321-31. doi: 10.1016/j.neuron.2005.02.018.
Certain goal-directed behaviors depend upon interactions between basolateral amygdala (ABL) and orbitofrontal cortex (OFC). Here we describe neurophysiological evidence of this cooperative function. We recorded from ABL in intact and OFC-lesioned rats during learning of odor discrimination problems and reversals. During learning, rats with ipsilateral OFC lesions exhibited a marked decline in the proportion of ABL neurons that fired differentially during cue sampling both before and after reversal and in the proportion of neurons that reversed odor preference when the odor-outcome associations were reversed. This decline appeared to reflect a loss of rapid flexibility in cue selectivity that characterized activity in intact rats. In addition, lesioned rats had fewer neurons that fired in anticipation of the predicted outcome during a delay period after responding but before outcome delivery. These findings support a role for OFC in facilitating the encoding of information about expected outcomes in ABL.
某些目标导向行为依赖于基底外侧杏仁核（ABL）与眶额皮质（OFC）之间的相互作用。在此，我们描述了这种协同功能的神经生理学证据。在完整大鼠和OFC损伤大鼠学习气味辨别问题及逆转过程中，我们记录了ABL的活动。在学习过程中，同侧OFC损伤的大鼠在逆转前后的线索采样期间差异放电的ABL神经元比例，以及在气味-结果关联逆转时逆转气味偏好的神经元比例均显著下降。这种下降似乎反映了完整大鼠所具有的线索选择性快速灵活性的丧失。此外，损伤大鼠在做出反应但结果传递前的延迟期内，预期预测结果时放电的神经元较少。这些发现支持了OFC在促进ABL中关于预期结果信息编码方面的作用。
