Tasaka K, Nakaya N, Code C F
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Methods Find Exp Clin Pharmacol. 1992 Nov;14(9):667-75.
The effect of chronic administration of histamine on the number of cells in peripheral blood of dogs, rabbits and guinea pigs was tested by single and consecutive intramuscular injections of histamine in a beeswax-sesame oil mixture. Leukocytosis due to increased numbers of neutrophils occurred in all animals after single injections of histamine in beeswax, although erythrocytes and hematocrit values were unaffected in all species. When injection of histamine was repeated on consecutive days, the extent of leukocytosis subsided in some cases; however, the simultaneous administration of aminoguanidine restored leukocytosis. Single or daily injections of the beeswax-sesame oil mixture without histamine had none of these effects in any animals tested. Although simultaneous injections of histamine and H1 receptor antagonists did not alter histamine effects, the combined administrations of histamine and H2 receptor blocking agents suppressed histamine-induced leukocytosis.
通过在蜂蜡 - 芝麻油混合物中单次和连续肌肉注射组胺，测试了长期给予组胺对狗、兔子和豚鼠外周血中细胞数量的影响。在单次向蜂蜡中注射组胺后，所有动物均出现因中性粒细胞数量增加导致的白细胞增多，尽管所有物种的红细胞和血细胞比容值均未受影响。当连续数天重复注射组胺时，某些情况下白细胞增多的程度会减轻；然而，同时给予氨基胍可恢复白细胞增多。在任何受试动物中，单次或每日注射不含组胺的蜂蜡 - 芝麻油混合物均无上述这些作用。虽然同时注射组胺和H1受体拮抗剂不会改变组胺的作用，但组胺与H2受体阻断剂联合给药可抑制组胺诱导的白细胞增多。
