Dyck Michael K, Lacroix Dan, Pothier François, Sirard Marc-André
Centre de Recherche en Biologie de la Reproduction, Dépt des Sciences Animals, Pavillon Paul Comtois, Cité Universitaire, Université Laval, Sainte-Foy, Québec, Canada, G1K 7P4.
Trends Biotechnol. 2003 Sep;21(9):394-9. doi: 10.1016/S0167-7799(03)00190-2.
Transgenic animal bioreactors represent a powerful tool to address the growing need for therapeutic recombinant proteins. The ability of transgenic animals to produce complex, biologically active recombinant proteins in an efficient and economic manner has stimulated a great deal of interest in this area. As a result, genetically modified animals of several species, expressing foreign proteins in various tissues, are currently being developed. However, the generation of transgenic animals is a cumbersome process and remains problematic in the application of this technology. The advantages and disadvantages of different transgenic systems in relation to other bioreactor systems are discussed.
转基因动物生物反应器是满足对治疗性重组蛋白日益增长需求的有力工具。转基因动物以高效且经济的方式生产复杂的、具有生物活性的重组蛋白的能力，激发了该领域的极大兴趣。因此，目前正在培育几个物种的转基因动物，使其在各种组织中表达外源蛋白。然而，转基因动物的培育是一个繁琐的过程，并且在该技术的应用中仍然存在问题。本文讨论了不同转基因系统相对于其他生物反应器系统的优缺点。
