从自下而上和自上而下的角度设计氧化还原金属蛋白。
Designing redox metalloproteins from bottom-up and top-down perspectives.
作者信息
Barker Paul D
机构信息
University of Cambridge, Chemical Laboratory and Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK.
出版信息
Curr Opin Struct Biol. 2003 Aug;13(4):490-9. doi: 10.1016/s0959-440x(03)00108-8.
The design of redox-active metalloproteins has been approached from two different directions. The de novo design approach has recently reached an important stage, at which structural information on several different designed metalloproteins has been obtained. This new information highlights the real challenge of this approach. The alternative approach involving re-engineering of evolved proteins has also made significant advances recently.
氧化还原活性金属蛋白的设计主要从两个不同方向展开。从头设计方法最近已进入一个重要阶段，在此阶段已获得了几种不同设计的金属蛋白的结构信息。这些新信息凸显了该方法面临的实际挑战。另一种涉及对进化后的蛋白质进行重新设计的方法最近也取得了重大进展。
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