Kelders W P A, Kleinrensink G J, van der Geest J N, Feenstra L, de Zeeuw C I, Frens M A
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
J Physiol. 2003 Nov 15;553(Pt 1):311-7. doi: 10.1113/jphysiol.2003.049338. Epub 2003 Aug 29.
The cervico-ocular reflex (COR) is an ocular stabilization reflex that is elicited by rotation of the neck. It works in conjunction with the vestibulo-ocular reflex (VOR) and the optokinetic reflex (OKR) in order to prevent visual slip over the retina due to self-motion. The gains of the VOR and OKR are known to decrease with age. We have investigated whether the COR, a reflexive eye movement elicited by rotation of the neck, shows a compensatory increase and whether a synergy exists between the COR and the other ocular stabilization reflexes. In the present study 35 healthy subjects of varying age (20-86 years) were rotated in the dark in a trunk-to-head manner (the head fixed in spaced with the body passively rotated under it) at peak velocities between 2.1 and 12.6 deg s-1 as a COR stimulus. Another 15 were subjected to COR, VOR and OKR stimuli at frequencies between 0.04 and 0.1 Hz. Three subjects participated in both tests. The position of the eyes was recorded with an infrared recording technique. We found that the COR-gain increases with increasing age and that there is a significant covariation between the gains of the VOR and COR, meaning that when VOR increases, COR decreases and vice versa. A nearly constant phase lag between the COR and the VOR of about 25 deg existed at all stimulus frequencies.
颈眼反射（COR）是一种由颈部旋转引发的眼球稳定反射。它与前庭眼反射（VOR）和视动反射（OKR）协同作用，以防止因自身运动导致视网膜上的视觉图像滑动。已知VOR和OKR的增益会随着年龄增长而降低。我们研究了由颈部旋转引发的反射性眼球运动COR是否会出现代偿性增加，以及COR与其他眼球稳定反射之间是否存在协同作用。在本研究中，35名年龄各异（20 - 86岁）的健康受试者在黑暗中以躯干到头的方式旋转（头部固定，身体在其下方被动旋转），峰值速度在2.1至12.6度/秒之间，作为COR刺激。另外15名受试者接受了频率在0.04至0.1赫兹之间的COR、VOR和OKR刺激。三名受试者参与了两项测试。使用红外记录技术记录眼睛的位置。我们发现COR增益随着年龄增长而增加，并且VOR和COR的增益之间存在显著的协变关系，即当VOR增加时，COR降低，反之亦然。在所有刺激频率下，COR和VOR之间存在约25度的近乎恒定的相位滞后。
