原发性干燥综合征中的心血管自主神经功能障碍

Cardiovascular autonomic dysfunction in primary Sjögren's syndrome.

作者信息

Kovács László, Paprika Dóra, Tákacs Róbert, Kardos Attila, Várkonyi Tamás T, Lengyel Csaba, Kovács Attila, Rudas László, Pokorny Gyula

机构信息

Department of Rheumatology, Faculty of Medicine, University of Szeged, Szeged, Hungary.

出版信息

Rheumatology (Oxford). 2004 Jan;43(1):95-9. doi: 10.1093/rheumatology/keg468. Epub 2003 Aug 29.

DOI:10.1093/rheumatology/keg468

PMID:12949253

Abstract

OBJECTIVE

To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS).

METHODS

Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed.

RESULTS

The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P < 0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P < 0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P < 0.0001).

CONCLUSION

Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

摘要

目的

评估原发性干燥综合征（pSS）中心血管自主神经系统功能障碍的发生情况及其临床意义。

方法

51例pSS患者参与了这项病例对照研究。进行了心率和血压变异性测量、自发性压力反射敏感性检查以及心血管反射测试。

结果

pSS患者的心率和血压变异性测量结果以及压力反射敏感性参数在559名健康对照者数据库的最低百分位数范围内达到峰值（P < 0.05）。在五项心血管反射测试中的三项中，患者中异常结果的频率显著高于对照组（P < 0.05），自主神经病变的中位数评分也升高（对照组为0，患者组为3；P < 0.0001）。