小鼠中的治疗性克隆。
Therapeutic cloning in the mouse.
作者信息
Mombaerts Peter
机构信息
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1(Suppl 1):11924-5. doi: 10.1073/pnas.1934141100. Epub 2003 Aug 29.
Abstract
Nuclear transfer technology can be applied to produce autologous differentiated cells for therapeutic purposes, a concept termed therapeutic cloning. Countless articles have been published on the ethics and politics of human therapeutic cloning, reflecting the high expectations from this new opportunity for rejuvenation of the aging or diseased body. Yet the research literature on therapeutic cloning, strictly speaking, is comprised of only four articles, all in the mouse. The efficiency of derivation of embryonic stem cell lines via nuclear transfer is remarkably consistent among these reports. However, the efficiency is so low that, in its present form, the concept is unlikely to become widespread in clinical practice.
摘要
核移植技术可用于生产用于治疗目的的自体分化细胞，这一概念被称为治疗性克隆。关于人类治疗性克隆的伦理和政治问题，已经发表了无数文章，反映出人们对这个使衰老或患病身体恢复活力的新机会寄予了很高期望。然而，严格来讲，关于治疗性克隆的研究文献仅包含四篇文章，且均以小鼠为研究对象。这些报告中通过核移植获得胚胎干细胞系的效率非常一致。然而，效率如此之低，以至于就目前的形式而言，这个概念不太可能在临床实践中广泛应用。
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