Nakashima Misako, Reddi A Hari
Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Nat Biotechnol. 2003 Sep;21(9):1025-32. doi: 10.1038/nbt864.
Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development, the demonstration of stem cells in dental pulp and accumulating knowledge on biomaterial scaffolds have set the stage for tissue engineering and regenerative therapy of the craniofacial complex. Furthermore, the recent approval by the US Food and Drug Administration (FDA; Rockville, MD, USA) of recombinant human BMPs for accelerating bone fusion in slow-healing fractures indicates that this protein family may prove useful in designing regenerative treatments in dental applications. In the near term, these advances are likely to be applied to endodontics and periodontal surgery; ultimately, they may facilitate approaches to regenerating whole teeth for use in tooth replacement.
在理解骨形态发生蛋白（BMPs）在颅面和牙齿发育中的作用方面取得的进展、牙髓中干细胞的发现以及对生物材料支架的认识不断积累，为颅面复合体的组织工程和再生治疗奠定了基础。此外，美国食品药品监督管理局（FDA；美国马里兰州罗克维尔）最近批准重组人BMPs用于加速愈合缓慢的骨折中的骨融合，这表明该蛋白家族可能在设计牙科应用的再生治疗中有用。在短期内，这些进展可能会应用于牙髓病学和牙周手术；最终，它们可能会促进用于牙齿替换的全牙再生方法的发展。
