Bruner R H, Keller W F, Stitzel K A, Sauers L J, Reer P J, Long P H, Bruce R D, Alden C L
Pathology Associates, Inc., West Chester, Ohio 45069-3866.
Toxicol Pathol. 1992;20(3 Pt 1):357-66. doi: 10.1177/019262339202000306.
Groups of young, sexually mature Fischer-344 rats (n = 25/sex) obtained from commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocular tissues. Results disclosed a high incidence of corneal basement membrane dystrophy in rats of both sexes from all breeders; however, severity levels were significantly increased in rats obtained from one breeder when compared to others. Furthermore, rats that displayed the most advanced corneal lesions also exhibited more severe basement membrane changes in other organs, especially renal tubules and vascular internal laminae. These findings suggest that both ocular and nonocular dystrophic changes may have been linked through common physiologic (or genetic) mechanisms. Animals that displayed basement membrane lesions were not considered to represent compromised biologic test systems.
从商业饲养者处获得的年轻、性成熟的Fischer-344大鼠组（每组25只，雌雄各半）接受了眼科和组织病理学检查，以确定角膜基底膜病变（角膜营养不良）的患病率和严重程度，以及选定非眼部组织中的基底膜变化。结果显示，所有饲养者提供的雌雄大鼠角膜基底膜营养不良的发生率都很高；然而，与其他饲养者提供的大鼠相比，从一个饲养者处获得的大鼠的严重程度显著增加。此外，表现出最严重角膜病变的大鼠在其他器官，特别是肾小管和血管内皮层，也表现出更严重的基底膜变化。这些发现表明，眼部和非眼部的营养不良性变化可能通过共同的生理（或遗传）机制联系在一起。表现出基底膜病变的动物不被认为代表有缺陷的生物测试系统。
