Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56121 Pisa, Italy.
Interuniversity Consortium -Biostructures and Biosystems National Institute (INBB), Via Medaglie d'Oro 305, 00136 Roma, Italy.
Nutrients. 2021 Feb 27;13(3):770. doi: 10.3390/nu13030770.
Retinal diseases can be induced by a variety of factors, including gene mutations, environmental stresses and dysmetabolic processes. The result is a progressive deterioration of visual function, which sometimes leads to blindness. Many treatments are under investigation, though results are still mostly unsatisfactory and restricted to specific pathologies, particularly in the case of gene therapy. The majority of treatments have been tested in animal models, but very few have progressed to human clinical trials. A relevant approach is to study the relation between the type of treatments and the degenerative characteristics of the animal model to better understand the effectiveness of each therapy. Here we compare the results obtained from different animal models treated with natural compounds (saffron and naringenin) to anticipate the potentiality of a single treatment in different pathologies.
视网膜疾病可以由多种因素引起，包括基因突变、环境压力和代谢失调过程。其结果是视觉功能的进行性恶化，有时会导致失明。许多治疗方法正在研究中，尽管结果仍然大多不尽如人意，并且仅限于特定的病理，特别是在基因治疗的情况下。大多数治疗方法已经在动物模型中进行了测试，但很少有进展到人体临床试验。一种相关的方法是研究治疗类型与动物模型退行性特征之间的关系，以更好地了解每种治疗的效果。在这里，我们比较了用天然化合物（藏红花和柚皮素）治疗的不同动物模型的结果，以预测单一治疗在不同病理中的潜力。
