Lazarevic M B, Vitic J, Mladenovic V, Myones B L, Skosey J L, Swedler W I
Department of Medicine, University of Illinois, Chicago.
Semin Arthritis Rheum. 1992 Dec;22(3):172-8. doi: 10.1016/0049-0172(92)90017-8.
Concentrations of serum lipids and serum very low-density lipoproteins and low-density lipoproteins (VLDL+LDL, originally called beta lipoproteins) were measured and agarose gel electrophoresis of serum lipoproteins was performed in 69 patients with active rheumatoid arthritis (RA), 40 patients with psoriatic arthritis (PA), 21 patients with osteoarthritis (OA), and 65 healthy blood donors. These lipid parameters were also compared in 21 RA and 40 PA patients during periods of severe disease activity (SA) versus minimal disease activity (MA). RA patients had significantly decreased concentrations of total serum lipids, total serum cholesterol, cholesterol in LDL, and cholesterol in high-density lipoproteins (HDL) compared with healthy blood donors. RA patients with SA had significantly decreased cholesterol in LDL and HDL compared with patients with MA. As the disease activity decreased, RA patients had normalization of almost all serum lipid concentrations. Electrophoresis of serum lipoproteins showed heterogeneous patterns in RA patients. Patients with PA also had some evidence of dyslipoproteinemia. Serum lipids changed with disease activity in PA patients in a manner similar to that in RA patients. These data show that patients with RA and PA have a dyslipoproteinemia that is related to disease activity.
对69例活动期类风湿关节炎（RA）患者、40例银屑病关节炎（PA）患者、21例骨关节炎（OA）患者及65名健康献血者测定了血清脂质、血清极低密度脂蛋白和低密度脂蛋白（VLDL + LDL，原称β脂蛋白）的浓度，并进行了血清脂蛋白的琼脂糖凝胶电泳。还对21例RA患者和40例PA患者在疾病严重活动期（SA）与最小疾病活动期（MA）期间的这些脂质参数进行了比较。与健康献血者相比，RA患者的总血清脂质、总血清胆固醇、LDL中的胆固醇和高密度脂蛋白（HDL）中的胆固醇浓度显著降低。与MA患者相比，SA的RA患者LDL和HDL中的胆固醇显著降低。随着疾病活动度降低，RA患者几乎所有血清脂质浓度均恢复正常。RA患者血清脂蛋白电泳显示出异质性模式。PA患者也有一些血脂蛋白异常的证据。PA患者血清脂质随疾病活动度的变化方式与RA患者相似。这些数据表明，RA和PA患者存在与疾病活动度相关的血脂蛋白异常。
