Lazarevic M B, Vitic J, Myones B L, Mladenovic V, Nanusevic N, Skosey J L, Swedler W I
Institute for Rheumatology, Medical School of Belgrade, Yugoslavia.
Semin Arthritis Rheum. 1993 Jun;22(6):385-91. doi: 10.1016/s0049-0172(05)80030-7.
Antibodies against very low-density lipoproteins and low-density lipoproteins (aLA) were found in 26 of 69 (38%) patients with active rheumatoid arthritis (RA) but not in any control subjects (ie, 40 patients with psoriatic arthritis, 21 patients with osteoarthritis, and 65 healthy blood donors). In 21 RA patients (30%), lipoproteins were found in the dissociated components of circulating immune complexes. RA patients with aLA had significantly decreased cholesterol levels in all lipoprotein fractions and total serum lipids, while serum triglycerides were significantly increased compared with RA patients without aLA. Anticardiolipin antibodies as measured by the Venereal Disease Research Laboratory test were not found in any subject in this study. These findings suggest a possible autoimmune origin of dyslipoproteinemia in some patients with active RA.
在69例活动期类风湿关节炎（RA）患者中，有26例（38%）检测到抗极低密度脂蛋白和低密度脂蛋白抗体（aLA），而在任何对照受试者中均未检测到（即40例银屑病关节炎患者、21例骨关节炎患者和65例健康献血者）。在21例RA患者（30%）中，在循环免疫复合物的解离成分中发现了脂蛋白。与无aLA的RA患者相比，有aLA的RA患者所有脂蛋白组分和总血清脂质中的胆固醇水平显著降低，而血清甘油三酯显著升高。本研究中任何受试者均未检测到通过性病研究实验室试验测定的抗心磷脂抗体。这些发现提示，部分活动期RA患者的血脂蛋白异常可能源于自身免疫。
