Harsch I A, Konturek P C, Koebnick C, Kuehnlein P P, Fuchs F S, Pour Schahin S, Wiest G H, Hahn E G, Lohmann T, Ficker J H
Medical Dept 1, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Eur Respir J. 2003 Aug;22(2):251-7. doi: 10.1183/09031936.03.00010103.
Serum leptin and ghrelin levels were investigated in patients with obstructive sleep apnoea (OSA) syndrome before and during continuous positive airways pressure (CPAP) treatment and compared with body mass index (BMI)-matched controls without OSA. Male patients (n=30) with OSA (apnoea/hypopnoea index=58+/-16, BMI=32.6+/-5.3 kg x m(-2)) underwent CPAP treatment. Fasting leptin and ghrelin were measured at baseline and 2 days, and in the case of leptin 2 months after initiation of treatment. Baseline plasma ghrelin levels were significantly higher in OSA patients than in controls. After 2 days of CPAP treatment, plasma ghrelin decreased in almost all OSA patients (n=9) to levels that were only slightly higher than those of controls (n=9). Leptin levels did not change significantly from baseline after 2 days of CPAP treatment, but were higher than in the control group. After 8 weeks, leptin levels decreased significantly, although the BMI of the patients showed no change. The decrease in leptin levels was more pronounced in patients with a BMI <30 kg x m(-2). These data indicate that the elevated leptin and ghrelin levels are not determined by obesity alone, since they rapidly decreased during continuous positive airways pressure therapy.
对阻塞性睡眠呼吸暂停（OSA）综合征患者在持续气道正压通气（CPAP）治疗前及治疗期间的血清瘦素和胃饥饿素水平进行了研究，并与无OSA的体重指数（BMI）匹配的对照组进行比较。30例男性OSA患者（呼吸暂停/低通气指数=58±16，BMI=32.6±5.3kg·m⁻²）接受了CPAP治疗。在基线、治疗2天以及（瘦素检测）治疗开始2个月时测量空腹瘦素和胃饥饿素水平。OSA患者的基线血浆胃饥饿素水平显著高于对照组。CPAP治疗2天后，几乎所有OSA患者（n=9）的血浆胃饥饿素下降至仅略高于对照组（n=9）的水平。CPAP治疗2天后，瘦素水平与基线相比无显著变化，但高于对照组。8周后，尽管患者的BMI无变化，但瘦素水平显著下降。BMI<30kg·m⁻²的患者瘦素水平下降更为明显。这些数据表明，瘦素和胃饥饿素水平升高并非仅由肥胖决定，因为它们在持续气道正压通气治疗期间迅速下降。
