Bouchoucha M, Faye A, Devroede G, Arsac M
Hôpital Laennec, Laboratoire de Physiologie digestive, Paris, France.
Biomed Pharmacother. 2000 Aug;54(7):381-7. doi: 10.1016/S0753-3322(01)80005-6.
We have recently developed a simple method to investigate the colonic response to food (CRF). This study describes the modifications of CRF induced by treatment with oral pinaverium bromide in irritable bowel syndrome (IBS) patients. Thirty healthy subjects and 43 patients suffering from IBS were studied. Colonic transit time (CTT) was measured in fasting conditions and after eating a standard test meal. Colonic response to food was quantified by calculating the variation in number of markers in each zone of interest of the large bowel between the X-ray films of the abdomen taken before and after eating. CRF is characterized by caudal propulsion of colonic contents in the two groups. In controls, there is emptying of the caecum-ascending colon region and filling of the rectosigmoid. In IBS patients, only the left transverse colon and the splenic flexure empty. Pinaverium bromide exerts no effect in controls but reverses the CRF of the right colon in IBS patients by inhibiting right colon emptying. These results suggest that the inhibitory action of pinaverium bromide on CRF may support the clinical efficacy of this calcium channel blocker in the treatment of IBS.
我们最近开发了一种简单的方法来研究结肠对食物的反应（CRF）。本研究描述了口服匹维溴铵治疗对肠易激综合征（IBS）患者CRF的影响。对30名健康受试者和43名IBS患者进行了研究。在空腹状态下以及进食标准试验餐后测量结肠运输时间（CTT）。通过计算进食前后腹部X光片之间大肠各感兴趣区域标记物数量的变化来量化结肠对食物的反应。两组中CRF的特征均为结肠内容物向尾部推进。在对照组中，盲肠-升结肠区域排空，直肠乙状结肠充盈。在IBS患者中，只有左横结肠和脾曲排空。匹维溴铵对对照组无作用，但通过抑制右半结肠排空逆转IBS患者右半结肠的CRF。这些结果表明，匹维溴铵对CRF的抑制作用可能支持这种钙通道阻滞剂在IBS治疗中的临床疗效。
