Puente-Maestu L, Luisa Sánz M, Sánz P, de Oña Ruíz J M, Arnedillo A, Casaburi R
Hospital General Universitario Gregorio Marañón, Servicio de Neumología, Dr Ezquerdo 46, 28007 Madrid, Spain.
Lung. 2003;181(2):67-78. doi: 10.1007/s00408-003-1007-0.
The evaluation of a 13-month maintenance program (MP) for 39 severe COPD patients with FEV(1)%pred 44(7)% who, as result of two different 8-week leg exercise training (LET) programs, one supervised at the hospital (group S; n = 20) and the other self-monitored (SM; n = 19), had achieved different levels of exercise tolerance. After LET, patients in group S had a higher maximal oxygen uptake and endurance time than patients in the SM group [ O(2)max 1.43(0.30) l. min(-1)] vs l.25(0.27) l. min(-1) and endurance-time 16(4) min vs 12 (5) min, respectively). During the MP patients were advised to walk vigorously at least 4 km/day, 4 times/wk. After the MP, while endurance time remained higher than at baseline, it had decreased ( p < 0.01) immediately after LET in both groups and no differences were evident between groups (11(4) min and 10(4), respectively). In contrast, Chronic Respiratory Diseases Questionnaire scores, which had improved significantly after LET in both groups, remained high. Long-term effects of MP were independent of the training strategy or whether physiological improvements had been obtained with the initial LET. SM exercise programs do not seem capable of maintaining physiological improvements in exercise tolerance, though "quality of life" can be maintained.
对39例重度慢性阻塞性肺疾病(COPD)患者进行了为期13个月的维持计划(MP)评估,这些患者的预测第一秒用力呼气容积(FEV₁)%为44(7)%。由于接受了两种不同的为期8周的腿部运动训练(LET)计划,一种是在医院监督下进行(S组;n = 20),另一种是自我监测(SM组;n = 19),他们获得了不同程度的运动耐力。LET后,S组患者的最大摄氧量和耐力时间高于SM组患者[最大摄氧量分别为1.43(0.30)升·分钟⁻¹和1.25(0.27)升·分钟⁻¹,耐力时间分别为16(4)分钟和12(5)分钟]。在MP期间,建议患者每周4次、每天至少快走4公里。MP后,虽然耐力时间仍高于基线水平,但两组在LET后立即下降(p < 0.01),且两组之间无明显差异(分别为11(4)分钟和10(4)分钟)。相比之下,两组在LET后均显著改善的慢性呼吸系统疾病问卷评分仍保持较高水平。MP的长期效果与训练策略无关,也与最初的LET是否取得生理改善无关。SM运动计划似乎无法维持运动耐力的生理改善,尽管“生活质量”可以维持。