Guo Yu, Xu Mingmin, Ji Meiqi, Zhang Jialei, Hu Qingchuan, Wei Zeren, Yan Jian, Chen Yue, Lyu Jiaxuan, Shao Xiaoqian, Wang Ying, Guo Jiamei, Wei Yulong
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing.
Ovation Health Science and Technology Co. Ltd, ENN Group, Langfang.
Medicine (Baltimore). 2018 Oct;97(40):e12659. doi: 10.1097/MD.0000000000012659.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide with a substantial and increasing social and economic burden. Liuzijue Qigong is a kind of traditional Chinese Qigong exercises that Traditional Chinese Medicine practitioners prescribe to individuals with COPD to strengthen the internal organs' function. Liuzijue Qigong was recommended for use in COPD rehabilitation, and some clinical trials indicate that Liuzijue Qigong would produce better functional capacity and quality of life of individuals with COPD. The objective of this study is to conduct a systematic review of the existing studies to assess effectiveness and safety of Liuzijue Qigong for the prevention or treatment of COPD in patients.
We will perform the comprehensive literature search in English and Chinese electronic database. The publication period will be from inception to the search date. In addition, the clinical trial registries, dissertations, informal publication, grey literature, reference lists of studies, systematic reviews, and conference abstracts will also be collected. Two reviewers will identify relevant studies, extract data information, and then assess the methodical quality by the Cochrane risk of bias assessment tool. Only randomized controlled trials comparing Liuzijue Qigong against other intervention or nonintervention will be included. Data will be synthesized by either fixed-effect or random-effect model regarding to a heterogeneity test. The routine lung function, arterial blood gas tensions, partial pressure of carbon dioxide, functional capacity, 30 seconds sit-to-stand test, respiratory function, maximal inspiration pressure, maximal expiratory pressure, airway resistance, and specific airway conductance will be assessed as primary outcomes. The secondary outcomes involved dyspnea, and fatigue levels, respiratory muscle strength, upper and lower limb muscle strength, handgrip strength test, and health-related quality of life and safety. Meta-analysis will be performed by using Cochrane's Review Manager software (version 5.3.5).
This systematic review and meta-analysis will provide a high-quality synthesis and evaluate the efficacy and safety based on current relevant literature evidence of Liuzijue Qigong intervention for COPD patient.
Our systematic review will provide evidence to determine whether Liuzijue Qigong is an effective and safe approach to prevention and treatment of COPD patients.
慢性阻塞性肺疾病（COPD）是全球发病和死亡的主要原因，社会和经济负担巨大且不断增加。六字诀气功是一种传统的中国气功练习方法，中医从业者会为慢性阻塞性肺疾病患者开此功法以增强内脏功能。六字诀气功被推荐用于慢性阻塞性肺疾病的康复治疗，一些临床试验表明，六字诀气功可改善慢性阻塞性肺疾病患者的功能能力和生活质量。本研究的目的是对现有研究进行系统评价，以评估六字诀气功预防或治疗慢性阻塞性肺疾病患者的有效性和安全性。
我们将在英文和中文电子数据库中进行全面的文献检索。发表时间范围为创刊至检索日期。此外，还将收集临床试验注册库、学位论文、非正式出版物、灰色文献、研究的参考文献列表、系统评价和会议摘要。两名评审员将识别相关研究，提取数据信息，然后使用Cochrane偏倚风险评估工具评估方法学质量。仅纳入比较六字诀气功与其他干预措施或不干预措施的随机对照试验。将根据异质性检验，采用固定效应或随机效应模型对数据进行综合分析。常规肺功能、动脉血气张力、二氧化碳分压、功能能力、30秒坐立试验、呼吸功能、最大吸气压力、最大呼气压力、气道阻力和比气道传导率将作为主要结局进行评估。次要结局包括呼吸困难、疲劳水平、呼吸肌力量、上肢和下肢肌肉力量、握力测试以及健康相关生活质量和安全性。将使用Cochrane系统评价管理器软件（版本5.3.5）进行荟萃分析。
本系统评价和荟萃分析将基于当前六字诀气功干预慢性阻塞性肺疾病患者的相关文献证据，提供高质量的综合分析并评估其疗效和安全性。
我们的系统评价将为确定六字诀气功是否为预防和治疗慢性阻塞性肺疾病患者的有效且安全的方法提供证据。
