Nace C S, Szepesi B
J Nutr. 1976 Feb;106(2):285-91. doi: 10.1093/jn/106.2.285.
The role of dietary unsaturated fat in the control of hepatic glucose-6-phosphate dehydrogenase (G6PD) (EC 1.1.1.49) and malic enzyme (ME) (EC 1.1.1.40) was studied in rats subjected to one or two cycles of starvation-refeeding. Rats starved and refed a control (5% corn oil) diet showed a threefold increase in G6PD activity and a twofold increase in ME activity compared to ad libitum-fed rats. After a second cycle of starvation-refeeding G6PD and ME activities showed fourfold and threefold increases, respectively, as compared to ad libitum-fed rats. Feeding rats diets containing 8% linoleic acid (as triglycerides) prevented the increase in G6PD and ME activities upon starvation-refeeding, diets with oleic, palmitic, and stearic acis when fed did not prevent this increase. Feeding rats various combinations of linoleic, linolenic and oleic acids following starvation prevented the additional increase in G6PD and ME activities after a second starvation-refeeding cycle; however, linoleic acid fed alone during the first refeeding prevented the additional increase in ME activity but not in G6PD activity. It is suggested that the dietary control of these enzymes involves one or more specific polyunsaturated fatty acids.
在经历一个或两个饥饿-再喂养周期的大鼠中，研究了膳食不饱和脂肪在控制肝脏葡萄糖-6-磷酸脱氢酶（G6PD）（EC 1.1.1.49）和苹果酸酶（ME）（EC 1.1.1.40）方面的作用。与自由采食的大鼠相比，饥饿后再喂食对照（5%玉米油）饮食的大鼠G6PD活性增加了三倍，ME活性增加了两倍。在第二个饥饿-再喂养周期后，与自由采食的大鼠相比，G6PD和ME活性分别增加了四倍和三倍。给大鼠喂食含8%亚油酸（作为甘油三酯）的饮食可防止饥饿-再喂养后G6PD和ME活性的增加，喂食油酸、棕榈酸和硬脂酸的饮食则不能防止这种增加。饥饿后给大鼠喂食亚油酸、亚麻酸和油酸的各种组合可防止第二个饥饿-再喂养周期后G6PD和ME活性的进一步增加；然而，在第一次再喂养期间单独喂食亚油酸可防止ME活性的进一步增加，但不能防止G6PD活性的进一步增加。提示这些酶的膳食控制涉及一种或多种特定的多不饱和脂肪酸。
