Rudy Sherrill Jantzi
Department of Dermatology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center in Pittsburgh, PA, USA.
Pediatr Nurs. 2003 Jul-Aug;29(4):287-93; quiz 294-5.
Acne vulgaris is a disease of the pilosebaceous unit where abnormally adherent keratinocytes cause plugging of the follicular duct followed by accumulation of sebum, keratinous debris, and bacteria within this structure. It remains one of the most common inflammatory dermatoses among adolescents and is frequently seen in newborns in both pediatric and dermatology practices. This article summarizes the key factors involved in the pathogenesis of acne, reviews the clinical evaluation process, and clarifies the rationale for the selection of specific therapies. The psychosocial impact of acne is also addressed, including its impact on quality of life. The overarching goal is to prescribe effective therapy early to avoid both clinical and psychologic scarring along with ensuring adequate patient education for optimizing treatment outcomes.
寻常痤疮是一种毛囊皮脂腺疾病，异常黏附的角质形成细胞导致毛囊导管堵塞，随后在该结构内皮脂、角质碎屑和细菌积聚。它仍然是青少年中最常见的炎症性皮肤病之一，在儿科和皮肤科门诊中，新生儿也经常出现。本文总结了痤疮发病机制中的关键因素，回顾了临床评估过程，并阐明了选择特定治疗方法的基本原理。还讨论了痤疮的社会心理影响，包括其对生活质量的影响。总体目标是尽早开出有效的治疗方案，以避免临床和心理上的瘢痕形成，并确保对患者进行充分的教育以优化治疗效果。
