Grützmacher P, Tsobanelis T, Roth P, Werner E, Vlachojannis J, Kaltwasser J, Kurz P, Scheuermann E H, Schoeppe W
II. Medizinische Klinik, St.-Markus-Krankenhaus, Frankfurt/Main, Germany.
Clin Nephrol. 1992;38 Suppl 1:S92-7.
Iron deficiency is the main reason for insufficient response to rEPO therapy. Serum ferritin and transferrin saturation give valuable information on storage iron and iron transport. Iron demand for correction of anemia can easily be estimated after HCT (vol%) x average blood volume (dl) = mg iron. Inadequate iron supply of the bone marrow in the presence of sufficient storage iron in the RES develops frequently under rEPO, possibly explaining the improvement of bone marrow response to rEPO by concomitant intravenous iron supply. The reasons of functional iron deficiency are still speculative.
缺铁是对重组促红细胞生成素（rEPO）治疗反应不足的主要原因。血清铁蛋白和转铁蛋白饱和度可提供有关储存铁和铁转运的重要信息。贫血校正所需的铁量可通过血细胞比容（体积%）×平均血容量（分升）=铁毫克数轻松估算。在网状内皮系统（RES）储存铁充足的情况下，骨髓铁供应不足在rEPO治疗期间经常出现，这可能解释了静脉补充铁剂可改善骨髓对rEPO的反应。功能性缺铁的原因仍属推测。
