Threlfall E J, Ward L R, Rowe B, Raghupathi S, Chandrasekaran V, Vandepitte J, Lemmens P
WHO Collaborating Centre for Phage Typing and Resistance in Enterobacteria, Central Public Health Laboratory, London, UK.
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):990-3. doi: 10.1007/BF01967788.
Sixteen multiple drug resistant strains of Salmonella typhi belonging to Vi-phage types E1 (14) and O (2) and isolated in Southeast India in 1991 were characterized. All strains were resistant to chloramphenicol and the majority to trimethoprim and ampicillin. In all strains these resistances were encoded by plasmids of the H1 incompatibility group with molecular weights ranging from 110 to 120 megadaltons. Physicians in European countries should be aware that treatment may fail if patients with typhoid fever who have recently returned from the Indian sub-continent are given first-line treatment with chloramphenicol, trimethoprim or ampicillin. With the possible exception of young children, ciprofloxacin is currently the best choice for treatment of such patients.
对1991年在印度东南部分离出的16株属于Vi噬菌体E1型（14株）和O型（2株）的多重耐药伤寒沙门氏菌菌株进行了特性分析。所有菌株均对氯霉素耐药，大多数对甲氧苄啶和氨苄西林耐药。在所有菌株中，这些耐药性由H1不相容群的质粒编码，分子量范围为110至120兆道尔顿。欧洲国家的医生应意识到，如果对最近从印度次大陆返回的伤寒热患者使用氯霉素、甲氧苄啶或氨苄西林进行一线治疗，治疗可能会失败。除幼儿外，环丙沙星目前是治疗此类患者的最佳选择。
