Penadés Rafael, Boget Teresa, Catalán Rosa, Bernardo Miquel, Gastó Cristobal, Salamero Manel
Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Schizophr Res. 2003 Oct 1;63(3):219-27. doi: 10.1016/s0920-9964(02)00359-6.
The aim of the present study is to test Brenner's model of cognitive functioning in schizophrenia. It is assumed that elementary cognitive disorders (attention and encoding) and complex cognitive disorders (recall, concept formation) reinforce each other. Cognitive disorders are supposed to cause detrimental effects on functional outcome. We used cognitive rehabilitation as a strategy to induce cognitive changes in 27 patients assigned to treatment groups following the cognitive modules of the Integrated Psychological Treatment (IPT). Ten schizophrenic patients without cognitive impairments worked as a control group. With only one minor conceptual change (replacing concept formation with executive function, a more comprehensive construct), we found that our data fitted with Brenner's model. A relationship has been found between neuropsychological improvements and higher levels of autonomy and social functioning. These findings have important implications not only for cognitive assessment but also for selecting targets in cognitive rehabilitation.
本研究的目的是检验布伦纳的精神分裂症认知功能模型。假定基本认知障碍（注意力和编码）与复杂认知障碍（回忆、概念形成）相互强化。认知障碍被认为会对功能结局产生不利影响。我们采用认知康复作为一种策略，对按照综合心理治疗（IPT）的认知模块分配到治疗组的27名患者诱导其认知改变。10名无认知障碍的精神分裂症患者作为对照组。仅经过一个微小的概念性改变（用执行功能取代概念形成，执行功能是一个更综合的结构），我们发现我们的数据符合布伦纳的模型。已发现神经心理学改善与更高水平的自主性和社会功能之间存在关联。这些发现不仅对认知评估具有重要意义，而且对认知康复中目标的选择也具有重要意义。
