• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脆弱拟杆菌血液及其他肠外样本分离株中脆弱溶素基因的流行情况。

Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples.

作者信息

Foulon Ina, Piérard Denis, Muyldermans Gaëtan, Vandoorslaer Kristof, Soetens Oriane, Rosseel Paul, Lauwers Sabine

机构信息

Department of Microbiology, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium.

出版信息

J Clin Microbiol. 2003 Sep;41(9):4428-30. doi: 10.1128/JCM.41.9.4428-4430.2003.

DOI:10.1128/JCM.41.9.4428-4430.2003
PMID:12958284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193814/
Abstract

Of 166 Bacteroides fragilis isolates, 26.2% of 103 isolates from blood and 20.6% of 63 extraintestinal isolates harbored the fragilysin gene (difference not statistically significant). Clinical characteristics and evolution were comparable in patients with B. fragilis bacteremia with or without this enterotoxin. Fragilysin seems not to be an important virulence factor in B. fragilis disease.

摘要

在166株脆弱拟杆菌分离株中，来自血液的103株分离株中有26.2%以及63株肠外分离株中有20.6%携带脆弱溶血素基因（差异无统计学意义）。有或无这种肠毒素的脆弱拟杆菌菌血症患者的临床特征和病程相似。脆弱溶血素似乎不是脆弱拟杆菌疾病中的重要毒力因子。

相似文献

1
Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples.脆弱拟杆菌血液及其他肠外样本分离株中脆弱溶素基因的流行情况。
J Clin Microbiol. 2003 Sep;41(9):4428-30. doi: 10.1128/JCM.41.9.4428-4430.2003.
2
Characterization of the Bacteroides fragilis pathogenicity island in human blood culture isolates.人血培养分离株中脆弱拟杆菌致病岛的特征分析。
Anaerobe. 2006 Feb;12(1):17-22. doi: 10.1016/j.anaerobe.2005.06.005. Epub 2005 Aug 15.
3
[Comparison of antimicrobial resistance patterns of enterotoxin gene positive and negative Bacteroides fragilis isolates].[产肠毒素基因阳性与阴性脆弱拟杆菌分离株的耐药模式比较]
Mikrobiyol Bul. 2005 Apr;39(2):145-52.
4
High prevalence of division II (cfiA positive) isolates among blood stream Bacteroides fragilis in Slovenia as determined by MALDI-TOF MS.MALDI-TOF MS 鉴定斯洛文尼亚血流感染脆弱拟杆菌 II 型（cfiA 阳性）分离株的高流行率。
Anaerobe. 2019 Aug;58:30-34. doi: 10.1016/j.anaerobe.2019.01.011. Epub 2019 Feb 1.
5
Bacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel disease.炎症性肠病患者中脆弱拟杆菌肠毒素基因序列
Emerg Infect Dis. 2000 Mar-Apr;6(2):171-4. doi: 10.3201/eid0602.000210.
6
Association of enterotoxigenic Bacteroides fragilis with bacteremia.产肠毒素脆弱拟杆菌与菌血症的关联。
Clin Infect Dis. 1996 Dec;23 Suppl 1:S83-6. doi: 10.1093/clinids/23.supplement_1.s83.
7
Purification and characterisation of recombinant Bacteroides fragilis toxin-2.重组脆弱拟杆菌毒素-2 的纯化与特性分析。
Biochimie. 2013 Nov;95(11):2123-31. doi: 10.1016/j.biochi.2013.08.005. Epub 2013 Aug 15.
8
Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis.产肠毒素脆弱拟杆菌脆弱溶素致病性岛的分子特征
Infect Immun. 1998 Apr;66(4):1735-9. doi: 10.1128/IAI.66.4.1735-1739.1998.
9
Detection of enterotoxin and protease genes among Hungarian clinical Bacteroides fragilis isolates.匈牙利临床分离脆弱拟杆菌中肠毒素和蛋白酶基因的检测
Anaerobe. 2017 Dec;48:98-102. doi: 10.1016/j.anaerobe.2017.07.005. Epub 2017 Jul 25.
10
The distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites.来自粪便标本和肠外部位的产肠毒素脆弱拟杆菌菌株中bft等位基因的分布情况。
Anaerobe. 2006 Apr;12(2):71-4. doi: 10.1016/j.anaerobe.2005.11.001. Epub 2005 Dec 13.

引用本文的文献

1
Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface.底物裂解谱分析提示脆弱拟杆菌金属蛋白酶（脆弱拟杆菌溶素和金属蛋白酶 II）在微生物组-炎症-癌症界面具有独特的功能。
J Biol Chem. 2013 Nov 29;288(48):34956-67. doi: 10.1074/jbc.M113.516153. Epub 2013 Oct 21.
2
Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.产肠毒素脆弱拟杆菌：共生菌中的异类。
Clin Microbiol Rev. 2009 Apr;22(2):349-69, Table of Contents. doi: 10.1128/CMR.00053-08.
3
Enterotoxigenic Bacteroides fragilis.产肠毒素脆弱拟杆菌。
Curr Infect Dis Rep. 2008 May;10(2):99-104. doi: 10.1007/s11908-008-0018-7.
4
Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment.针对小鼠肠道菌群的定量PCR检测揭示了菌群组成中受微环境影响的菌株依赖性差异。
Mamm Genome. 2006 Nov;17(11):1093-104. doi: 10.1007/s00335-006-0063-1. Epub 2006 Nov 7.
5
Characterization of Bacteroides fragilis hemolysins and regulation and synergistic interactions of HlyA and HlyB.脆弱拟杆菌溶血素的特性以及HlyA和HlyB的调控与协同相互作用
Infect Immun. 2006 Apr;74(4):2304-16. doi: 10.1128/IAI.74.4.2304-2316.2006.

本文引用的文献

1
Enterotoxigenic Bacteroides fragilis in Hungary.
Anaerobe. 1997 Apr-Jun;3(2-3):87-9. doi: 10.1006/anae.1997.0078.
2
Occurrence of Bacteroides fragilis enterotoxin gene-carrying strains in Germany and the United States.德国和美国携带脆弱拟杆菌肠毒素基因菌株的出现情况。
J Clin Microbiol. 2000 May;38(5):1996-7. doi: 10.1128/JCM.38.5.1996-1997.2000.
3
Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin.脆弱拟杆菌肠毒素可切割黏着小带蛋白E-钙黏蛋白。
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14979-84. doi: 10.1073/pnas.95.25.14979.
4
Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin.脆弱拟杆菌毒素（Fragilysin）的分子建模与分析
Clin Infect Dis. 1997 Sep;25 Suppl 2:S153-5. doi: 10.1086/516240.
5
Detection of enterotoxigenic Bacteroides fragilis and its toxin in stool samples from adults and children in Italy.意大利成人和儿童粪便样本中脆弱拟杆菌肠毒素的检测及其毒素检测
Clin Infect Dis. 1997 Jan;24(1):12-6. doi: 10.1093/clinids/24.1.12.
6
Association of enterotoxigenic Bacteroides fragilis with bacteremia.产肠毒素脆弱拟杆菌与菌血症的关联。
Clin Infect Dis. 1996 Dec;23 Suppl 1:S83-6. doi: 10.1093/clinids/23.supplement_1.s83.
7
Bacterial extracellular zinc-containing metalloproteases.细菌细胞外含锌金属蛋白酶
Microbiol Rev. 1993 Dec;57(4):823-37. doi: 10.1128/mr.57.4.823-837.1993.
8
Detection of intestinal and extra-intestinal strains of enterotoxigenic Bacteroides fragilis by the HT-29 cytotoxicity assay.采用HT-29细胞毒性试验检测产肠毒素脆弱拟杆菌的肠道及肠外菌株。
J Med Microbiol. 1994 Sep;41(3):191-6. doi: 10.1099/00222615-41-3-191.
9
Isolation of enterotoxigenic Bacteroides fragilis from Bangladeshi children with diarrhea: a controlled study.从孟加拉国腹泻儿童中分离产肠毒素脆弱拟杆菌：一项对照研究。
J Clin Microbiol. 1994 Apr;32(4):960-3. doi: 10.1128/jcm.32.4.960-963.1994.
10
The enterotoxin of Bacteroides fragilis is a metalloprotease.脆弱拟杆菌的肠毒素是一种金属蛋白酶。
Infect Immun. 1995 Jan;63(1):175-81. doi: 10.1128/iai.63.1.175-181.1995.