Sheu S-Y, Schmid K W
Institut für Pathologie, Universitätsklinikum Essen, Germany.
Pathologe. 2003 Sep;24(5):339-47. doi: 10.1007/s00292-003-0628-7. Epub 2003 Jun 19.
Inflammation of the thyroid gland makes up approximately 20% of all thyroid diseases. According to the clinical course, thyroiditis has been subdivided into acute, subacute, and chronic forms. Recent classifications are based on the fact that the majority of thyroiditis cases have an autoimmune background. The most common form of this disease is autoimmune thyroiditis (AIT), with or without subclinical/manifest hypothyroidism; less common forms of autoimmune thyroiditis comprise subacute granulomatous (de Quervain's) thyroiditis, postpartum thyroiditis, silent ("painless") thyroiditis, and invasive-sclerosing thyroiditis (Riedel's thyroiditis). Non-autoimmune thyroiditis is very rare (acute suppurative thyroiditis, radiation thyroiditis). Thyroiditis is both clinically and morphologically an important differential diagnosis of thyroid tumours. The present paper deals with the epidemiology, clinical course, and morphology of thyroiditis, knowledge of which is essential for the examination of cytological and histological thyroid specimens.
甲状腺炎症约占所有甲状腺疾病的20%。根据临床病程,甲状腺炎可分为急性、亚急性和慢性三种形式。最近的分类基于这样一个事实,即大多数甲状腺炎病例都有自身免疫背景。这种疾病最常见的形式是自身免疫性甲状腺炎(AIT),伴有或不伴有亚临床/显性甲状腺功能减退;自身免疫性甲状腺炎较不常见的形式包括亚急性肉芽肿性(德奎尔万氏)甲状腺炎、产后甲状腺炎、寂静性(“无痛性”)甲状腺炎和侵袭性硬化性甲状腺炎(里德尔氏甲状腺炎)。非自身免疫性甲状腺炎非常罕见(急性化脓性甲状腺炎、放射性甲状腺炎)。甲状腺炎在临床和形态学上都是甲状腺肿瘤重要的鉴别诊断。本文论述了甲状腺炎的流行病学、临床病程和形态学,了解这些知识对于甲状腺细胞学和组织学标本的检查至关重要。