Akutsu Kazuhiko, Kitagawa Mikiya, Nakazawa Hiroyuki, Makino Tsunehisa, Iwazaki Katsuhiko, Oda Hajime, Hori Shinjiro
Division of Food Chemistry, Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
Chemosphere. 2003 Nov;53(6):645-54. doi: 10.1016/S0045-6535(03)00764-1.
The time-trend and recent concentrations of polybrominated diphenyl ethers (PBDEs) in Japanese mother's milk were investigated. The time-trend of 16 PBDEs (BDE-28, 37, 47, 66, 71, 75, 77, 85, 99, 100, 119, 153, 154, 138, 183, and 190) in pooled milk samples from mothers living in Osaka between 1973 and 2000 was analyzed. Additionally, PBDE concentrations in individual milk samples collected from 13 mothers living in Kanagawa and Okayama in 1999 were measured. The total concentration of all PBDE congeners (SigmaPBDEs) measured in the pooled samples increased during the period between 1973 (<0.01 ng/g lipid) and 1988 (1.64 ng/g lipid), and remained low afterwards while showing remarkable changes in PBDE congener profiles. The SigmaPBDEs in the 1999 individual milk samples were also low (0.56-3.97 ng/g lipid), except for a single sample (291 ng/g lipid). The source of this exposure could not be identified.
对日本母乳中多溴二苯醚(PBDEs)的时间趋势和近期浓度进行了调查。分析了1973年至2000年期间居住在大阪的母亲们的混合母乳样本中16种多溴二苯醚(BDE-28、37、47、66、71、75、77、85、99、100、119、153、154、138、183和190)的时间趋势。此外,还测量了1999年从神奈川和冈山的13位母亲采集的个体母乳样本中的多溴二苯醚浓度。在混合样本中测得的所有多溴二苯醚同系物的总浓度(ΣPBDEs)在1973年(<0.01 ng/g脂质)至1988年(1.64 ng/g脂质)期间有所增加,之后保持在较低水平,同时多溴二苯醚同系物谱显示出显著变化。1999年个体母乳样本中的ΣPBDEs也较低(0.56 - 3.97 ng/g脂质),但有一个样本除外(291 ng/g脂质)。这种接触的来源无法确定。