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簕竹的抗炎和抗溃疡活性。

Antiinflammatory and antiulcer activities of Bambusa arundinacea.

作者信息

Muniappan M, Sundararaj T

机构信息

Department of Pharmacology, Sri Ramachandra Medical College and Research Institute (Deemed University), Porur, Chennai 600116, India.

出版信息

J Ethnopharmacol. 2003 Oct;88(2-3):161-7. doi: 10.1016/s0378-8741(03)00183-1.

Abstract

The extracts of Bambusa arundinacea have been used in Indian folk medicine to treat various inflammatory conditions. The plant has got antiulcer activity also. It is thought that these two properties in the same extract are very much useful in the treatment of inflammatory conditions. It is well known fact that the most of the available antiinflammatory drugs are ulcerogenic. The antiinflammatory effect of the methanol extract of the leaves of Bambusa arundinacea against carrageenin-induced as well as immunologically induced paw oedema and also its antiulcer activity in albino rats have been studied and found to be significant when compared to the standard drugs. The combination of methanol extract and phenylbutazone (Non-Steroidal Antiinflammatory Agent, NSAIA) has been studied and found to be the most potent antiinflammatory activity experimentally with least toxic (no ulcerogenic) activity. Thus, the combination of herbal product (methanol extract of Bambusa arundinacea) with modern medicine (NSAIAs) will produce the best antiinflammatory drug and will be useful for long-term treatment of chronic inflammatory conditions like rheumatoid arthritis with peptic ulcer, which are common.

摘要

印度民间医学中,簕竹提取物被用于治疗多种炎症性疾病。该植物还具有抗溃疡活性。人们认为,同一提取物中的这两种特性对炎症性疾病的治疗非常有用。众所周知,大多数现有的抗炎药物都有溃疡形成的副作用。对簕竹叶甲醇提取物对角叉菜胶诱导的以及免疫诱导的爪肿胀的抗炎作用及其对白化大鼠的抗溃疡活性进行了研究,结果发现,与标准药物相比,其作用显著。对甲醇提取物与保泰松(非甾体抗炎药,NSAIA)的组合进行了研究,发现其在实验中具有最强的抗炎活性,且毒性最小(无溃疡形成副作用)。因此,草药产品(簕竹甲醇提取物)与现代医学药物(NSAIA)的组合将产生最佳的抗炎药物,对类风湿性关节炎伴消化性溃疡等常见慢性炎症性疾病的长期治疗将很有用。

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