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患者对给药所需片剂刻痕性能的体验。

Patient experiences with the performance of tablet score lines needed for dosing.

作者信息

Rodenhuis Nienke, de Smet Peter A, Barends Dirk M

机构信息

National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

出版信息

Pharm World Sci. 2003 Aug;25(4):173-6. doi: 10.1023/a:1024852529628.

DOI:10.1023/a:1024852529628
PMID:12964497
Abstract

OBJECTIVE

The aim of this study was to measure the experience of patients with score line tablets where breaking was necessary for dosing.

METHOD

In three community pharmacies in the Netherlands, patients were asked about their experiences with the functioning of the score line. The survey was restricted to scored tablets that had to be broken to obtain the prescribed dose. It was also asked what actions were taken by the patient when breaking problems were encountered.

RESULTS

Of all the score line prescriptions included in the study, 36% received a negative evaluation by the patient. The main negative experiences were related to loss of mass after breaking the tablets and difficulty in breaking, reported in 32% and 15%, respectively, of the prescriptions included in the study. In only 28% of the negative experiences had this been reported back to the pharmacy.

CONCLUSION

Many patients experience an unsatisfactory performance of tablets with score lines. Improvement will need a combination of technically better score lines and the alertness of the dispensing pharmacy for breaking problems.

摘要

目的

本研究旨在衡量需要掰开以进行给药的刻痕片患者的用药体验。

方法

在荷兰的三家社区药房,询问患者关于刻痕片功能的用药体验。该调查仅限于必须掰开以获得规定剂量的刻痕片。还询问了患者在遇到掰开问题时采取了什么行动。

结果

在本研究纳入的所有刻痕片处方中,36%得到了患者的负面评价。主要的负面体验分别与片剂掰开后质量损失和掰开困难有关,在本研究纳入的处方中,分别有32%和15%的处方报告了这些问题。在仅28%的负面体验中,这些问题被反馈回了药房。

结论

许多患者对刻痕片的使用体验不满意。改进需要技术上更好的刻痕以及配药药房对掰开问题的警觉性相结合。

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本文引用的文献

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Eur J Pharm Biopharm. 2002 Mar;53(2):139-45. doi: 10.1016/s0939-6411(01)00228-4.
2
Patients' evaluation of shape, size and colour of solid dosage forms.患者对固体剂型的形状、大小和颜色的评价。
Pharm World Sci. 2001 Oct;23(5):185-8. doi: 10.1023/a:1012050931018.
3
Accuracy of tablet splitting.片剂分割的准确性。
Sci Pharm. 2016 Oct 11;84(4):646-653. doi: 10.3390/scipharm84040646.
4
Relationship between Age and the Ability to Break Scored Tablets.年龄与掰开刻痕片剂能力之间的关系
Front Pharmacol. 2016 Jul 26;7:222. doi: 10.3389/fphar.2016.00222. eCollection 2016.
5
The use of oral suspension and rationally prescribing alternatives may be supplemental to the implementation of clopidogrel new algorithm comprising CYP2C19 pharmacogenetics and drug interactions.使用口服混悬剂并合理开具替代药物可能是对包含CYP2C19药物遗传学和药物相互作用的氯吡格雷新算法实施的补充。
Ther Clin Risk Manag. 2016 Mar 2;12:351-2. doi: 10.2147/TCRM.S103196. eCollection 2016.
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Weight and content uniformity of lorazepam half-tablets: A study of correlation of a low drug content product.劳拉西泮半片的重量和含量均匀度:对低药物含量产品相关性的研究。
Saudi Pharm J. 2013 Jan;21(1):71-5. doi: 10.1016/j.jsps.2011.12.009. Epub 2012 Jan 5.
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Prediction of the ease of subdivision of scored tablets from their physical parameters.从物理参数预测划痕片的可分割性。
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Bosn J Basic Med Sci. 2007 Nov;7(4):328-34. doi: 10.17305/bjbms.2007.3022.
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A composite screening tool for medication reviews of outpatients: general issues with specific examples.一种用于门诊患者药物评估的综合筛查工具:一般问题及具体示例
Drugs Aging. 2007;24(9):733-60. doi: 10.2165/00002512-200724090-00003.
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The frequency of inappropriate tablet splitting in primary care.基层医疗中不适当片剂分割的频率。
Eur J Clin Pharmacol. 2006 Dec;62(12):1065-73. doi: 10.1007/s00228-006-0202-3. Epub 2006 Oct 6.
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