Liquid infrared atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry of sialylated carbohydrates.

作者信息

Von Seggern Christopher E, Moyer Susanne C, Cotter Robert J

机构信息

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

出版信息

Anal Chem. 2003 Jul 1;75(13):3212-8. doi: 10.1021/ac0262006.

A 2.94-microm Er:YAG laser for IR atmospheric pressure matrix-assisted laser desorption/ionization on an ion trap mass spectrometer is used for the analysis of sialylated oligosaccharides. This approach provided the opportunity to utilize liquid matrixes and is effective in determining structural features--sequence, branching, and linkage--of intact, fully sialylated molecular species.