系统性红斑狼疮中的抗内皮细胞自身抗体与内皮细胞功能障碍的可溶性标志物
Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus.
作者信息
Constans Joel, Dupuy Remy, Blann Andrew D, Resplandy Francois, Seigneur Martine, Renard Martine, Longy-Boursier Maïte, Schaeverbeke Thierry, Guérin Viviane, Boisseau Michel R, Conri Claude
机构信息
Service de Médecine Interne et Pathologie Vasculaire, Hôpital Saint-André, 1 rue Jean Burguet, 33075 Bordeaux, France.
出版信息
J Rheumatol. 2003 Sep;30(9):1963-6.
OBJECTIVE
To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE).
METHODS
We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE.
RESULTS
Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021).
CONCLUSION
IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.
目的
确定抗内皮细胞抗体（AECA）及内皮细胞功能的血浆标志物是否与系统性红斑狼疮（SLE）的疾病严重程度相关。
方法
我们采用人脐静脉内皮细胞结合法检测AECA，采用酶联免疫吸附测定法（ELISA）检测内皮标志物血管性血友病因子、可溶性血栓调节蛋白及可溶性E选择素，并采用SLE疾病活动指数（SLEDAI）和系统性红斑狼疮国际协作临床诊治规范（SLICC/ACR）评估35例SLE患者的疾病严重程度。
结果
与21名健康对照相比，尽管SLE患者的IgG AECA（p = 0.001）和血管性血友病因子（p = 0.0007）水平较高，但我们仅发现IgG AECA与SLEDAI指数之间存在正相关（r = 0.393，p = 0.021）。
结论
IgG AECA似乎与SLE的疾病活动相关，可能具有致病作用。相反，内皮细胞损伤的血浆标志物似乎是一种附带现象，可能仅与炎症过度有关。
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