Pottumarthy Sudha, Moland Ellen Smith, Juretschko Stefan, Swanzy Susan R, Thomson Kenneth S, Fritsche Thomas R
University of Washington School of Medicine, Seattle, Washington, USA.
Emerg Infect Dis. 2003 Aug;9(8):999-1002. doi: 10.3201/eid0908.030096.
An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
从一名血液系统恶性肿瘤患者的血液中分离出一株耐亚胺培南的阴沟肠杆菌。分析性等电聚焦、抑制剂研究、水解试验、诱导试验和分子测序方法证实存在NmcA碳青霉烯水解酶。在北美检测到NmcA的这一首次报告值得对其分布和临床影响进行进一步调查。