大蒜素对表皮葡萄球菌的体外活性及亚抑菌浓度对生物膜形成的影响。
In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation.
作者信息
Pérez-Giraldo C, Cruz-Villalón G, Sánchez-Silos R, Martínez-Rubio R, Blanco M T, Gómez-García A C
机构信息
Department of Microbiology, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
出版信息
J Appl Microbiol. 2003;95(4):709-11. doi: 10.1046/j.1365-2672.2003.02030.x.
AIMS
The aim of this study is to determine the in vitro activity of allicin against Staphylococcus epidermidis and to evaluate the influence of allicin on biofilm formation.
METHODS AND RESULTS
In vitro activity of allicin (diallyl thiosulphinate) against 38 strains of S. epidermidis was investigated. The activity of allicin was similar against S. epidermidis methicillin susceptible and methicillin resistant strains [minimum inhibitory concentration (MIC)90=8 mg l(-1)]. In general, subinhibitory concentrations (sub-MIC) of allicin diminished biofilm formation in the five strains analysed.
CONCLUSION
The results confirm the antibacterial effect of allicin. Sub-MICs of allicin also diminished the biofilm formations by S. epidermidis.
SIGNIFICANCE AND IMPACT OF THE STUDY
The present study shows that allicin is active in vitro against S. epidermidis and that sub-MICs of allicin may play a role in the prevention of adherence of this bacteria to medical devices.
目的
本研究旨在确定大蒜素对表皮葡萄球菌的体外活性，并评估大蒜素对生物膜形成的影响。
方法与结果
研究了大蒜素（二烯丙基硫代亚磺酸盐）对38株表皮葡萄球菌的体外活性。大蒜素对甲氧西林敏感和甲氧西林耐药的表皮葡萄球菌菌株的活性相似[最低抑菌浓度（MIC）90 = 8 mg l(-1)]。总体而言，大蒜素的亚抑菌浓度（亚MIC）减少了所分析的5株菌株中的生物膜形成。
结论
结果证实了大蒜素的抗菌作用。大蒜素的亚MIC也减少了表皮葡萄球菌的生物膜形成。
研究的意义与影响
本研究表明大蒜素在体外对表皮葡萄球菌具有活性，且大蒜素的亚MIC可能在预防该细菌粘附于医疗设备方面发挥作用。
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