淋巴结内淋巴细胞运动和迁移的随机观点。

A stochastic view of lymphocyte motility and trafficking within the lymph node.

作者信息

Wei Sindy H, Parker Ian, Miller Mark J, Cahalan Michael D

机构信息

Departments of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.

出版信息

Immunol Rev. 2003 Oct;195:136-59. doi: 10.1034/j.1600-065x.2003.00076.x.

DOI:10.1034/j.1600-065x.2003.00076.x

PMID:12969316

Abstract

Two-photon microscopy is providing literal insight into the cellular dynamics of lymphoid organs and, guided by analysis of three-dimensional images, into mechanisms that underlie cell migration and antigen recognition in vivo. This review describes lymphocyte motility and antigen recognition in the native tissue environment and compares these results with a much more extensive literature on lymphocyte motility, signaling, and chemotaxis in vitro. We discuss the in vitro literature on dynamic aspects of lymphocyte motility, chemotaxis, and the response to antigen and present the view that random migration of lymphocytes may drive a stochastic mechanism of antigen recognition in lymphoid organs, rather than being guided by chemotaxis.

摘要

双光子显微镜正在为深入了解淋巴器官的细胞动力学提供切实的见解，并在三维图像分析的指导下，深入了解体内细胞迁移和抗原识别的机制。本综述描述了淋巴细胞在天然组织环境中的运动性和抗原识别，并将这些结果与关于淋巴细胞在体外的运动性、信号传导和趋化性的更为广泛的文献进行比较。我们讨论了关于淋巴细胞运动性、趋化性以及对抗原反应的动态方面的体外文献，并提出观点，即淋巴细胞的随机迁移可能驱动淋巴器官中抗原识别的随机机制，而不是由趋化作用引导。