Sarić M, Godnić-Cvar J, Marelja J
Institute for Medical Research and Occupational Health, University of Zagreb, Croatia.
Med Lav. 1992 Sep-Oct;83(5):418-21.
Two groups of workers were studied: a) 24 workers with respiratory complaints--7 of whom were light and 4 borderline hyper-reactors--who continued to work on the electrolytic reduction of aluminium for up to two years; b) 30 workers with increased bronchial reactivity who ceased to work in potrooms for 3.7 years on average (range 2-11 years) because of respiratory complaints. Subjective respiratory complaints were recorded and a non specific bronchial reactivity test was performed one or two times during the follow-up period. A sustained level of airway reactivity was recorded in both groups of workers regardless of exposure conditions. In workers with dyspnoea and airway obstruction, bronchial reactivity did not worsen in spite of continued exposure. On the other hand cessation of exposure was not followed by normalization of bronchial reactivity. The potential role of atopy, smoking habits and length of previous exposure was analyzed. It appears that increased bronchial reactivity, once induced, has a tendency to persist. An improvement in subjective complaints may be expected after cessation of exposure.
a）24名有呼吸系统症状的工人——其中7名症状较轻，4名接近高反应者——他们继续从事铝的电解还原工作长达两年；b）30名支气管反应性增强的工人，由于呼吸系统症状，他们平均有3.7年（范围为2至11年）未在电解车间工作。记录主观呼吸系统症状，并在随访期间进行一到两次非特异性支气管反应性测试。无论接触条件如何，两组工人均记录到持续的气道反应性水平。在有呼吸困难和气道阻塞的工人中，尽管持续接触，支气管反应性并未恶化。另一方面，停止接触后支气管反应性并未恢复正常。分析了特应性、吸烟习惯和既往接触时长的潜在作用。似乎一旦诱发，支气管反应性增强有持续的倾向。停止接触后，主观症状有望改善。
