食管正常组织与癌组织的傅里叶变换红外光谱分析
FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus.
作者信息
Wang Jian-Sheng, Shi Jing-Sen, Xu Yi-Zhuang, Duan Xiao-Yi, Zhang Li, Wang Jing, Yang Li-Ming, Weng Shi-Fu, Wu Jin-Guang
机构信息
Department of Oncological Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
出版信息
World J Gastroenterol. 2003 Sep;9(9):1897-9. doi: 10.3748/wjg.v9.i9.1897.
Abstract
AIM
To investigate the special Fourier transform infrared spectroscopy (FT-IR) spectra in normal and cancerous tissues of esophagus.
METHODS
Twenty-seven pairs of normal and cancerous tissues of esophagus were studied by using FT-IR and the special spectra characteristics were analyzed in different tissues.
RESULTS
Different spectra were found in normal and cancerous tissues. The peak at 1 550/cm was weak and wide in cancerous tissues but strong and high in normal tissues. The ratio of I 1 647/I 1 550 was 2.0 in normal tissues and 2.36 in cancerous tissues (P<0.05). The ratio of I 1 550/I 1 080 was 4.5 in normal tissues and 3.4 in cancerous tissues (P<0.01). The peak at 1453 /cm was higher than at 1 402/cm in normal tissue and lower than at 1 402/cm in cancerous tissues.
CONCLUSION
The results indicate that FTIR may be used in clinical diagnosis.
摘要
目的
研究食管正常组织和癌组织的特殊傅里叶变换红外光谱（FT-IR）。
方法
采用傅里叶变换红外光谱法对27对食管正常组织和癌组织进行研究，并分析不同组织的特殊光谱特征。
结果
正常组织和癌组织呈现出不同的光谱。癌组织中1550/cm处的峰弱且宽，而正常组织中该峰强且高。正常组织中I1647/I1550的比值为2.0，癌组织中为2.36（P<0.05）。正常组织中I1550/I1080的比值为4.5，癌组织中为3.4（P<0.01）。正常组织中1453/cm处的峰高于1402/cm处的峰，而癌组织中则低于1402/cm处的峰。
结论
结果表明傅里叶变换红外光谱可用于临床诊断。
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