Liu Guo-ying, Yao Hang-ping
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Aug;32(4):327-9. doi: 10.3785/j.issn.1008-9292.2003.04.014.
To study the role of interleukin(IL)18 and interferon gamma (IFN-Gamma) in the pathogenesis of condyloma acuminatum(CA).
Double antibody sandwich ELISA was used to measure the levels of IL-18 and IFN-Gamma in serum of 30 cases of CA.
The serum levels of IL-18 and IFN-Gamma of the CA patients were significantly higher than those of normal controls IL-18 132.00 +/-52.92 microg/L compared with 50.79 +/- 23.48 microg/L, P<0.01 IFN-Gamma:80.83 +/-20.46 microg/L compared with 20.71 +/-11.18 microg/L P <0.01) and IL-18 levels were positively correlated with IFN-Gamma concentrations (r=0.754, t=6.081, P <0.01).
These data suggest that during infection of human papilloma viruses, anti-infective immune responses are activated.
研究白细胞介素（IL）-18和干扰素γ（IFN-γ）在尖锐湿疣（CA）发病机制中的作用。
采用双抗体夹心ELISA法检测30例CA患者血清中IL-18和IFN-γ水平。
CA患者血清中IL-18和IFN-γ水平显著高于正常对照组（IL-18：132.00±52.92μg/L，正常对照组为50.79±23.48μg/L，P<0.01；IFN-γ：80.83±20.46μg/L，正常对照组为20.71±11.18μg/L，P<0.01），且IL-18水平与IFN-γ浓度呈正相关（r=0.754，t=6.081，P<0.01）。
这些数据表明，在人乳头瘤病毒感染期间，抗感染免疫反应被激活。
