Sostarić B, Peraica M, Fuchs R
Institute for Medical Research, Zagreb, Croatia.
Arh Hig Rada Toksikol. 1992 Dec;43(4):365-72.
Basic field studies related to the animal population were performed in the region of Slavonski Brod, Republic of Croatia, where Balkan endemic nephropathy is an endemic disease. Pathological changes in several animal species from the locality were examined. The pig population in the area is numerous. Morphologically and physiologically pigs make an excellent animal model for studies of human diseases. Their use in studies should be encouraged, especially because there is a possibility that pigs and humans suffer from the same type of intoxication with a specific xenobiotic of natural origin. According to the mycotoxin theory about the aetiology of Balkan endemic nephropathy, pork meat might be one of the possible hazards for humans. Experiments on laboratory animals provide an excellent possibility to monitor several aspects of pathogenesis and all stages of pathomorphological changes which might then be correlated with Balkan endemic nephropathy. However, the experimental species should be critically chosen because some spontaneous, species-specific lesions of the kidneys are easily mistaken for changes induced experimentally.
在克罗地亚共和国斯拉沃尼亚布罗德地区开展了与动物种群相关的基础实地研究，该地区是巴尔干地方性肾病的流行区。对当地几种动物物种的病理变化进行了检查。该地区猪的数量众多。从形态学和生理学角度来看，猪是研究人类疾病的优秀动物模型。应鼓励在研究中使用猪，特别是因为猪和人类有可能因一种特定的天然来源外源性物质而遭受同类型的中毒。根据关于巴尔干地方性肾病病因的霉菌毒素理论，猪肉可能是对人类的潜在危害之一。对实验动物进行实验为监测发病机制的多个方面以及病理形态变化的各个阶段提供了绝佳机会，这些变化随后可能与巴尔干地方性肾病相关联。然而，实验物种的选择应谨慎，因为一些肾脏的自发性、物种特异性病变很容易被误认为是实验诱导的变化。
