Doshi Seema N, Friedman Paul M, Marquez Denise K, Goldberg Leonard H
Department of Dermatology, University of Texas Houston Medical School, USA.
Dermatol Surg. 2003 Oct;29(10):1008-11. doi: 10.1046/j.1524-4725.2003.29292.x.
Advancements in nonablative laser technology necessitate concurrent developments in topical anesthesia, as patients have reported varying degrees of discomfort during these procedures. Although topical anesthetics have proven efficacious, they possess inherent limitations related to ease of use.
To evaluate the efficacy of the S-Caine Peel (ZARS Inc., Salt Lake City, UT), a novel topical anesthetic that dries to form a flexible membrane, for induction of anesthesia after only a 30-minute application period.
Twenty patients received concurrent 30-minute applications of both the S-Caine Peel and a placebo cream randomized to the right and left cheeks in a double-blinded manner. After one pass of the 1450-nm diode laser (Smoothbeam, Candela Corp., Wayland, MA), patients' pain levels were recorded on a visual analog scale (VAS). Both the investigator and an independent observer rated perceived discomfort and immediate skin reaction based on a numerical scale.
Differences in VAS scores between active sites (average rating of 15 mm) and placebo sites (average rating of 47 mm) were statistically significant (P<0.001). A painless procedure was noted at 50% and 65% of active sites by the independent observer and investigator, respectively. This was statistically different (P<0.001) from the independent observer and investigator perception of pain-free procedure at the placebo site, 0% and 5%, respectively.
The S-Caine Peel provided effective and safe dermal anesthesia after only a 30-minute application period for nonablative laser treatment with the 1450-nm diode laser. The unique vehicle readily delivers anesthetic to contoured regions of the body and eliminates the need for occlusion.
非剥脱性激光技术的进步使得局部麻醉需要同步发展，因为患者报告在这些手术过程中存在不同程度的不适。尽管局部麻醉剂已被证明有效，但它们在易用性方面存在固有局限性。
评估S-Caine Peel（ZARS公司，犹他州盐湖城）的疗效，这是一种新型局部麻醉剂，干燥后形成柔性膜，仅需涂抹30分钟即可诱导麻醉。
20名患者以双盲方式在左右脸颊同时涂抹S-Caine Peel和安慰剂乳膏30分钟，随机分组。在使用1450纳米二极管激光（Smoothbeam，康黛拉公司，马萨诸塞州韦兰）照射一次后，用视觉模拟量表（VAS）记录患者的疼痛程度。研究者和独立观察者根据数字量表对感知到的不适和即时皮肤反应进行评分。
活性部位（平均评分为15毫米）和安慰剂部位（平均评分为47毫米）的VAS评分差异具有统计学意义（P<0.001）。独立观察者和研究者分别在50%和65%的活性部位观察到无痛手术。这与独立观察者和研究者在安慰剂部位分别为0%和5%的无痛手术感知在统计学上有差异（P<0.001）。
S-Caine Peel仅需涂抹30分钟，就能为1450纳米二极管激光非剥脱性激光治疗提供有效且安全的皮肤麻醉。这种独特的载体能将麻醉剂轻松输送到身体的轮廓部位，无需封闭。
