He Yao, Jiang Yong, Xing Yu-bin, Zhong Guang-lin, Wang Lei, Sun Zheng-ji, Jia Hong, Chang Qing, Wang Yong, Ni Bin, Chen Shi-ping
Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jul;24(7):554-6.
To study the transmission route of severe acute respiratory syndrome (SARS) nosocomial infection.
Ten identified SARS patients were selected from a general hospital in March. Survey was carried out through a standardized questionnaire provided by Chinese Center for Disease Control and Prevention. Contents of the questionnaire would include: history of contact with SARS patient, route of infection, methods used for protection and so on.
(1) Distribution os SARS patients were confined to 3 wards: 4, 5, and 6 on the 7, 8, 12, 13 and 14 floors in the west unit of the inpatient building. Most of the inpatients were elderly and having severe original diseases. (2) Index patients were the first generation source of transmission and they infected inpatients and medical staff, making them the second generation. People with latent infection who had close contact with SARS patients might also serve as the possible source of transmission. (3) The major transmission routes were: near distant droplet infection and close contact infection. There was also a clue to the probability of aerosol or droplet nuclei infection through air-conditioning and ventilation system.
Nosocomial infection appeared to be the main characteristic of the SARS epidemic in the early stage of this hospital. Other than close contact and near space airborne transmission of SARS virus, the possibility of long-distance aerosol transmission called for further epidemiological and experimental studies in the future.
研究严重急性呼吸综合征（SARS）医院感染的传播途径。
3月从一家综合医院选取10例确诊的SARS患者。通过中国疾病预防控制中心提供的标准化问卷进行调查。问卷内容包括：与SARS患者的接触史、感染途径、防护措施等。
（1）SARS患者分布在住院楼西区7、8、12、13和14层的4、5、6三个病房。住院患者大多为老年人且原有严重疾病。（2）首例患者是第一代传染源，他们感染了住院患者和医务人员，使其成为第二代传染源。与SARS患者密切接触的隐性感染者也可能成为传染源。（3）主要传播途径为：近距离飞沫传播和密切接触传播。通过空调和通风系统存在气溶胶或飞沫核感染的可能性线索。
医院感染似乎是本院SARS疫情早期的主要特征。除SARS病毒的密切接触和近距离空气传播外，远距离气溶胶传播的可能性有待未来进一步的流行病学和实验研究。
