Li Hai-lan, Feng Xiao-rong, Dai Lin, Yang Qing
Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Mar;24(3):355-8.
To investigate the epidemiological features of nosocomial infection of severe acute respiratory syndrome (SARS) in the medical staff of a hospital.
The medical staff associated with nosocomial infection of SARS in a hospital were investigated with standard procedures of epidemiological survey.
The source of SARS infection was identified as the husband of a tumor patient who received chemotherapy in the Department of Oncology, during which they maintained intimate contact for at least two weeks when the husband had typical symptoms of SARS. The tumor patient had no any signs of SARS before her death. The mean latent period of SARS was 12.6 days in the 8 nurses transferred temporarily from other departments to assist in the management of the tumor patient. All 57 persons with close contact with the 12 medical staff suffering SARS in the latent period or with one having early-stage SARS did not show any signs of SARS during one month for observation in isolation.
SARS patients may have no or very limited infectivity during the latent period. Infection of SARS might be concerned with the intensity and persistence of contact with the infectious sources. The pathogenesis of SARS might involve the immune status of the potential patients, and immunodeficient individuals are at the risk of becoming asymptomatic carriers of SARS virus and the infectious sources.
调查某医院医务人员严重急性呼吸综合征（SARS）医院感染的流行病学特征。
采用流行病学调查的标准程序，对某医院发生SARS医院感染的医务人员进行调查。
SARS感染源为一名在肿瘤科接受化疗的肿瘤患者的丈夫，在其出现SARS典型症状时，两人密切接触至少两周。该肿瘤患者生前无任何SARS迹象。临时从其他科室调来协助管理该肿瘤患者的8名护士中，SARS平均潜伏期为12.6天。与12名处于潜伏期或有1名处于SARS早期的SARS医务人员密切接触的57人，在隔离观察1个月期间均未出现任何SARS迹象。
SARS患者在潜伏期可能无传染性或传染性极有限。SARS感染可能与接触传染源的强度和持续时间有关。SARS的发病机制可能涉及潜在患者的免疫状态，免疫功能低下者有成为SARS病毒无症状携带者和传染源的风险。
